2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140090
    N-(Boc-PEG1)-N-bis(PEG2-propargyl) 2100306-63-4
    N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-(Boc-PEG1)-N-bis(PEG2-propargyl)
  • HY-140908
    Biotin-PEG6-Mal 1808990-66-0 98.96%
    Biotin-PEG6-Mal is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG6-Mal
  • HY-141276
    Methyltetrazine-amido-PEG5-alkyne 2322322-23-4
    Methyltetrazine-amido-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-amido-PEG5-alkyne
  • HY-138363
    Azido-PEG6-MS 352439-38-4
    Azido-PEG6-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-MS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-MS
  • HY-124386
    DBCO-NHCO-PEG4-amine 1255942-08-5
    DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively).
    DBCO-NHCO-PEG4-amine
  • HY-140315
    m-PEG4-NH-DBCO 2228857-36-9
    m-PEG4-NH-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG4-NH-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    m-PEG4-NH-DBCO
  • HY-133328
    Amino-PEG13-amine 1228119-65-0 98.00%
    Amino-PEG13-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG13-amine
  • HY-130478
    m-PEG4-CH2COOH 16024-66-1 99.86%
    m-PEG4-CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG4-CH2COOH
  • HY-130377
    Propargyl-PEG8-bromide 2055046-25-6
    Propargyl-PEG8-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-bromide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG8-bromide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG8-bromide
  • HY-130820
    THP-PEG4-Pyrrolidine(N-Boc)-CH2OH 2378261-80-2
    THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523).
    THP-PEG4-Pyrrolidine(N-Boc)-CH2OH
  • HY-136140
    Aldehyde-benzyl-PEG5-alkyne 1378928-83-6
    Aldehyde-benzyl-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aldehyde-benzyl-PEG5-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Aldehyde-benzyl-PEG5-alkyne
  • HY-140536
    N-(Boc-PEG3)-N-bis(PEG3-acid) 2055042-61-8
    N-(Boc-PEG3)-N-bis(PEG3-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(Boc-PEG3)-N-bis(PEG3-acid)
  • HY-140572
    N-Mal-N-bis(PEG4-NHS ester) 2112738-60-8
    N-Mal-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Mal-N-bis(PEG4-NHS ester)
  • HY-140251
    Tri(Amino-PEG5-amide)-amine 2055013-52-8 99.86%
    Tri(Amino-PEG5-amide)-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tri(Amino-PEG5-amide)-amine
  • HY-133401
    endo-BCN-PEG3-NH2 1883512-27-3 99.64%
    endo-BCN-PEG3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG3-NH2 is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG3-NH2
  • HY-138372
    Br-PEG4-THP 1803547-60-5
    Br-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Br-PEG4-THP
  • HY-23629
    16-Aminohexadecanoic acid 17437-22-8 98.0%
    16-Aminohexadecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. 16-Aminohexadecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
    16-Aminohexadecanoic acid
  • HY-140001
    Amino-PEG3-C2-sulfonic acid 1817735-43-5 99.47%
    Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG3-C2-sulfonic acid
  • HY-132087
    Bromo-PEG7-alcohol 86220-35-1 ≥98.0%
    Bromo-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG7-alcohol
  • HY-140246
    N-(PEG3-acid)-N-bis(PEG3-amine) 2183440-35-7
    N-(PEG3-acid)-N-bis(PEG3-amine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(PEG3-acid)-N-bis(PEG3-amine)
PROTAC Linkers Isoform Comparison

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